RapamycinFungusV1, Main, Exploration, bibRecord, 000B50

An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast.

Identifieur interne : 000B50 ( Main/Exploration ); précédent : 000B49; suivant : 000B51

An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast.

Auteurs : Witawas Handee [États-Unis] ; Xiaobo Li [États-Unis] ; Kevin W. Hall [États-Unis] ; Xiexiong Deng [États-Unis] ; Pan Li [États-Unis] ; Christoph Benning [États-Unis] ; Barry L. Williams [États-Unis] ; Min-Hao Kuo [États-Unis]

Source :

PLoS genetics [ 1553-7404 ] ; 2016.

RBID : pubmed:26907989

Descripteurs français

KwdFr :
- Diacylglycerol O-acyltransferase (génétique), Diacylglycerol O-acyltransferase (métabolisme), Mutation (MeSH), Métabolisme énergétique (MeSH), Paraquat (pharmacologie), Protéines de Saccharomyces cerevisiae (génétique), Protéines de Saccharomyces cerevisiae (métabolisme), Saccharomyces cerevisiae (effets des médicaments et des substances chimiques), Saccharomyces cerevisiae (physiologie), Sirolimus (pharmacologie), Triacylglycerol lipase (génétique), Triacylglycerol lipase (métabolisme), Triglycéride (métabolisme).
MESH :
- effets des médicaments et des substances chimiques : Saccharomyces cerevisiae.
- génétique : Diacylglycerol O-acyltransferase, Protéines de Saccharomyces cerevisiae, Triacylglycerol lipase.
- métabolisme : Diacylglycerol O-acyltransferase, Protéines de Saccharomyces cerevisiae, Triacylglycerol lipase, Triglycéride.
- pharmacologie : Paraquat, Sirolimus.
- physiologie : Saccharomyces cerevisiae.
- Mutation, Métabolisme énergétique.

English descriptors

KwdEn :
- Diacylglycerol O-Acyltransferase (genetics), Diacylglycerol O-Acyltransferase (metabolism), Energy Metabolism (MeSH), Lipase (genetics), Lipase (metabolism), Mutation (MeSH), Paraquat (pharmacology), Saccharomyces cerevisiae (drug effects), Saccharomyces cerevisiae (physiology), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Sirolimus (pharmacology), Triglycerides (metabolism).
MESH :
- chemical , genetics : Diacylglycerol O-Acyltransferase, Lipase, Saccharomyces cerevisiae Proteins.
- chemical , metabolism : Diacylglycerol O-Acyltransferase, Lipase, Saccharomyces cerevisiae Proteins, Triglycerides.
- chemical , pharmacology : Paraquat, Sirolimus.
- drug effects : Saccharomyces cerevisiae.
- physiology : Saccharomyces cerevisiae.
- Energy Metabolism, Mutation.

Abstract

Intracellular triacylglycerol (TAG) is a ubiquitous energy storage lipid also involved in lipid homeostasis and signaling. Comparatively, little is known about TAG's role in other cellular functions. Here we show a pro-longevity function of TAG in the budding yeast Saccharomyces cerevisiae. In yeast strains derived from natural and laboratory environments a correlation between high levels of TAG and longer chronological lifespan was observed. Increased TAG abundance through the deletion of TAG lipases prolonged chronological lifespan of laboratory strains, while diminishing TAG biosynthesis shortened lifespan without apparently affecting vegetative growth. TAG-mediated lifespan extension was independent of several other known stress response factors involved in chronological aging. Because both lifespan regulation and TAG metabolism are conserved, this cellular pro-longevity function of TAG may extend to other organisms.

DOI: 10.1371/journal.pgen.1005878
PubMed: 26907989
PubMed Central: PMC4764362

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<term>Lipase (genetics)</term>
<term>Lipase (metabolism)</term>
<term>Mutation (MeSH)</term>
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<term>Protéines de Saccharomyces cerevisiae (métabolisme)</term>
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<front><div type="abstract" xml:lang="en">Intracellular triacylglycerol (TAG) is a ubiquitous energy storage lipid also involved in lipid homeostasis and signaling. Comparatively, little is known about TAG's role in other cellular functions. Here we show a pro-longevity function of TAG in the budding yeast Saccharomyces cerevisiae. In yeast strains derived from natural and laboratory environments a correlation between high levels of TAG and longer chronological lifespan was observed. Increased TAG abundance through the deletion of TAG lipases prolonged chronological lifespan of laboratory strains, while diminishing TAG biosynthesis shortened lifespan without apparently affecting vegetative growth. TAG-mediated lifespan extension was independent of several other known stress response factors involved in chronological aging. Because both lifespan regulation and TAG metabolism are conserved, this cellular pro-longevity function of TAG may extend to other organisms. </div>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>08</Month>
<Day>17</Day>
</PubMedPubDate>
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<ArticleIdList><ArticleId IdType="pubmed">26907989</ArticleId>
<ArticleId IdType="doi">10.1371/journal.pgen.1005878</ArticleId>
<ArticleId IdType="pii">PGENETICS-D-15-02056</ArticleId>
<ArticleId IdType="pmc">PMC4764362</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Cell Death Differ. 2010 May;17(5):763-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20075938</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Genet. 2010 Apr;6(4):e1000921</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20421943</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Endocrinology. 2011 Jan;152(1):48-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21106876</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Appl Microbiol Biotechnol. 2011 May;90(4):1429-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21431397</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Cycle. 2011 May 1;10(9):1385-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21447998</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2011 Sep;17(9):1076-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21857651</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Subcell Biochem. 2012;57:123-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22094420</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2011 Dec;189(4):1177-201</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22174183</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2012 Apr;1821(4):607-17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22289388</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Protoplasma. 2012 Jul;249(3):541-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22002710</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Metab. 2012 Jul 3;16(1):18-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22768836</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Physiol Biochem. 2012;30(2):307-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22739135</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Genet. 2012;8(8):e1002912</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22916041</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Cycle. 2012 Oct 1;11(19):3532-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22951542</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Genet. 2012;8(11):e1003064</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23166516</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2012;7(11):e46198</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23185233</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eukaryot Cell. 2012 Dec;11(12):1451-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23042128</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2013 Jan 2;309(1):71-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23280227</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Genet. 2013 Nov;59(4):231-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24057105</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oxid Med Cell Longev. 2013;2013:327167</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24175011</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2013 Dec 13;288(50):36061-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24187129</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Yeast. 2013 Dec;30(12):501-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24185677</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Rep. 2014 Jan 16;6(1):44-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24373967</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Genet. 2014 Feb;10(2):e1004113</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24516402</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mech Ageing Dev. 2014 Jan;135:41-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24373996</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Genet. 2014 Feb;10(2):e1004168</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24586198</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurobiol Aging. 1999 Sep-Oct;20(5):479-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10638521</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2000 May 26;275(21):15609-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10747858</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2001 Apr 13;292(5515):288-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11292860</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2002 Feb 22;277(8):6478-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11741946</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2002 Mar 15;277(11):8877-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11751875</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Microbiol. 2002 Dec;5(6):602-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12457705</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2003 Jan;163(1):35-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12586694</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2003 Jun 27;278(26):23317-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12682047</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Aging Cell. 2003 Apr;2(2):73-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12882320</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2003 Nov 21;278(47):47145-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12963726</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Microbiol Mol Biol Rev. 2004 Jun;68(2):187-206</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15187181</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Microbiol. 2004 Sep;53(5):1407-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15387819</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Aging Knowledge Environ. 2004 Sep 29;2004(39):pe36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15456908</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biochem. 1972 May;71(5):783-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4561339</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 1979 Nov 21;575(2):204-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">389291</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 1984 Jul;37(3):969-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6378388</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 1988 May;2(5):517-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3290050</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lipids. 1989 Jul;24(7):625-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2674578</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Methods Enzymol. 1991;194:132-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2005783</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Bacteriol. 1992 Apr;174(7):2352-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1551852</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 1992 Mar 25;20(6):1425</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1561104</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 1994 Apr;169(4):859-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8133102</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Yeast. 1994 Dec;10(13):1793-808</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7747518</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1996 May 24;271(21):12275-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8647826</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Yeast. 1999 Oct;15(14):1541-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10514571</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1959 Jun 20;183(4677):1751-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">13666896</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2004 Nov 19;306(5700):1383-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15550674</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2005 Mar;25(5):1655-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15713625</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mech Ageing Dev. 2005 Sep;126(9):987-1002</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15893363</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2005 Sep;25(18):8387-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16135825</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2005 Nov 11;280(45):37301-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16135509</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2006 Jan 6;281(1):491-500</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16267052</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2006 Jan 15;20(2):174-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16418483</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2006 May 5;312(5774):734-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16675698</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2006 Jul;26(13):4818-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16782871</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Biol. 2006 Jul 3;174(1):89-100</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16818721</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eukaryot Cell. 2006 Jul;5(7):1018-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16835446</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochimie. 2007 Feb;89(2):243-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16919863</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann N Y Acad Sci. 2007 Apr;1100:505-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17460215</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2007 Jun;117(6):1679-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17510710</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Cycle. 2007 Jul 1;6(13):1574-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17603300</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12825-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17652520</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2007;2(8):e748</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17710147</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gerontol A Biol Sci Med Sci. 2008 Feb;63(2):113-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18314444</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Res. 2008 Apr;18(4):564-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18340043</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15166-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18812505</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioresour Technol. 2014 Mar;155:379-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24472680</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Microbiol. 2014 Dec;22:30-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25305535</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Endocrinol. 2015 Jan;11(1):55-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25265977</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Biol. 2015 Jun 1;25(11):R470-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26035793</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Cell Biol. 2015 Aug;35:91-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25988547</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2015 Oct 8;163(2):340-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26451484</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Genet. 2008 Oct;4(10):e1000223</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18927628</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2009 Jan 16;33(1):53-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19150427</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2009 Apr 3;284(14):9011-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19028688</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Lipid Res. 2009 Apr;50 Suppl:S69-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18955729</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Cycle. 2009 Apr 15;8(8):1256-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19305133</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Vis Exp. 2009;(27). pii: 1156. doi: 10.3791/1156</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19421136</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Genet. 2009 May;5(5):e1000467</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19424415</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Vis Exp. 2009;(28). pii: 1209. doi: 10.3791/1209</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19556967</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Cycle. 2009 Jul 15;8(14):2300-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19502784</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Biol Med. 2009 Sep 1;47(5):469-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19500666</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exp Gerontol. 2009 Sep;44(9):555-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19539741</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2009 Nov 6;284(45):30981-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19608739</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2009 Dec 25;284(52):36312-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19778901</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2010 Jan;30(2):537-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19917722</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Lipid Res. 2010 Feb;51(2):262-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19965608</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2010 Mar;1801(3):266-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19782153</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Obesity (Silver Spring). 2010 Mar;18(3):456-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19798071</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2010 Mar 25;464(7288):513-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20336133</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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</country>
<region><li>Michigan</li>
</region>
</list>
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</region>
<name sortKey="Benning, Christoph" sort="Benning, Christoph" uniqKey="Benning C" first="Christoph" last="Benning">Christoph Benning</name>
<name sortKey="Deng, Xiexiong" sort="Deng, Xiexiong" uniqKey="Deng X" first="Xiexiong" last="Deng">Xiexiong Deng</name>
<name sortKey="Hall, Kevin W" sort="Hall, Kevin W" uniqKey="Hall K" first="Kevin W" last="Hall">Kevin W. Hall</name>
<name sortKey="Kuo, Min Hao" sort="Kuo, Min Hao" uniqKey="Kuo M" first="Min-Hao" last="Kuo">Min-Hao Kuo</name>
<name sortKey="Li, Pan" sort="Li, Pan" uniqKey="Li P" first="Pan" last="Li">Pan Li</name>
<name sortKey="Li, Xiaobo" sort="Li, Xiaobo" uniqKey="Li X" first="Xiaobo" last="Li">Xiaobo Li</name>
<name sortKey="Li, Xiaobo" sort="Li, Xiaobo" uniqKey="Li X" first="Xiaobo" last="Li">Xiaobo Li</name>
<name sortKey="Williams, Barry L" sort="Williams, Barry L" uniqKey="Williams B" first="Barry L" last="Williams">Barry L. Williams</name>
</country>
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	Serveur d'exploration sur la rapamycine et les champignons
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An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast.

An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast.

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